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Journal: bioRxiv
Article Title: Identification and SAR optimization of FBXO22-mediated TEAD Targeted Glue™ degraders
doi: 10.64898/2026.04.21.719895
Figure Lengend Snippet: a. TEAD protein levels in NCI-H226, determined by immunofluorescence, following 1H pre-treatment with DMSO (red) or 3 µM MLN4924 (blue) then 24 hours treatment with amine 1 . Data are from n = 1 biologically independent samples. b. Immunoblot of FBXO22 protein levels in HeLa WT and FBXO22 KO cell lines. Data are from n = 1 biologically independent sample. c. TEAD protein levels in parental HeLa WT or FBXO22 KO cell lines, determined by immunofluorescence, following 24 hours treatment with a dose response of PROTAC 16 . Data show the individual data points from n = 2 biologically independent samples.
Article Snippet:
Techniques: Immunofluorescence, Western Blot